Title: Mianserin and chronic pain: a double-blind placebo-controlled process and outcome study
Authors: Onghena, Patrick ×
De Cuyper, H
Van Houdenhove, Boudewijn
Verstraeten, D #
Issue Date: Sep-1993
Publisher: Munksgaard int publ ltd
Series Title: Acta psychiatrica Scandinavica vol:88 issue:3 pages:198-204
Abstract: There is evidence that antidepressants may have an analgesic effect in chronic pain. To replicate this effect and to throw light on the processes involved, a 12-week cross-over double-blind trial of mianserin versus placebo was carried out in 4 diagnostic groups: A) depressive patients without pain complaints (n = 8), B) depressive patients with chronic organic pain (n = 8), C) patients with somatoform pain disorder and vital signs of depression (n = 11) and D) patients with chronic organic pain without depression (n = 8). Although a mianserin-induced antidepressant effect in group A was evident, no significant pain reduction was accomplished in any group. The reasons for this failure to replicate the antidepressant-induced analgesic effect are discussed.
ISSN: 0001-690X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Methodology of Educational Sciences
Research Group Psychiatry
× corresponding author
# (joint) last author

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