Title: Quality of washed salvaged red blood cells during total hip replacement: a comparison between the use of heparin and citrate as anticoagulants
Authors: Mortelmans, Y ×
Vermaut, Gery
Van Aken, H
Goossens, Willy
Boogaerts, Marc #
Issue Date: Sep-1995
Series Title: Anesthesia and analgesia vol:79 issue:2 pages:357-63
Abstract: A randomized, prospective study comparing heparin with citrate (ACD) as anticoagulant during red blood cell saving was performed in 10 ASA grade I-II patients undergoing primary total hip replacement. Blood samples were taken before and after surgery and at several steps during cell saving. In the heparin group, salvaged red cells showed normal values, with the exception of decreased filtrability and moderate hemolysis. More differences in red cell quality were found in the ACD group. Mean corpuscular volume was higher (110 vs 95 x 10(-12) mL), red cell distribution was increased (17% vs 13%), osmotic resistance was lower (0.54 vs 0.43 g NaCl/L at 50% hemolysis), antioxidative reserve capacity was lower (1.9 vs 4.6 U glutathione reductase per gram of hemoglobin) and there was more hemolysis (15% vs 11%). Despite the small volume of autologous blood retransfused (388 +/- 92 mL), the differences in vitro produced significantly higher free hemoglobin levels in the patients' plasma at the end of the operation (58 vs 23 mg/dL). We conclude that heparin is preferable to citrate as an anticoagulant during autotransfusion with cell washing and immediate retransfusion.
ISSN: 0003-2999
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Hematology Section (-)
Laboratory of Clinical Bacteriology and Mycology
Anesthesiology and Algology
× corresponding author
# (joint) last author

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