Title: Safety, tolerability and efficacy of cyclosporine microemulsion in heart transplant recipients: A randomized, multicenter, double-blind comparison with the oil based formulation of cyclosporine - Results at six months after transplantation
Authors: Eisen, HJ ×
Hobbs, RE
Davis, SF
Laufer, G
Mancini, DM
Renlund, DG
Valantine, H
Ventura, H
Vachiery, JL
Bourge, RC
Canver, CC
Carrier, M
Costanzo, MR
Copeland, J
Dureau, G
Frazier, OH
Dorent, R
Hauptman, PJ
Kells, C
Masters, R
Michaud, JL
Paradis, I
Smith, A
Vanhaecke, Johan
Feutren, G
Turkin, D
Mellein, B
Mueller, EA #
Issue Date: Sep-1999
Publisher: Lippincott williams & wilkins
Series Title: Transplantation vol:68 issue:5 pages:663-671
Abstract: Background. The introduction of cyclosporine has resulted in significant improvement in the survival of cardiac allograft recipients due to decreased mortality from infection and rejection. The original oil-based cyclosporine formulation exhibits variable and unpredictable bioavailability that correlates with an increased incidence of acute and chronic rejection in those patients in whom this is mast pronounced. The primary objectives of this prospective, multicenter, randomized, double-blind study in cardiac transplant patients were: to compare the efficacy of cyclosporine microemulsion (CsA-NL) with oil-based cyclosporine (CsA-SM) as measured by cardiac allograft and recipient survival and the incidence and severity of acute rejection episodes; and to assess the safety and tolerability of CsA-NL compared with CsA-SM in this population. This report represents the analysis of results 6 months after transplantation.
ISSN: 0041-1337
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Cardiology
× corresponding author
# (joint) last author

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