Title: Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors
Authors: Rousseaux, Christel ×
Thuru, Xavier
Gelot, Agathe
Barnich, Nicolas
Neut, Christel
Dubuquoy, Laurent
Dubuquoy, Caroline
Merour, Emilie
Geboes, Karen
Chamaillard, Mathias
Ouwehand, Arthur
Leyer, Greg
Carcano, Didier
Colombel, Jean-Frédéric
Ardid, Denis
Desreumaux, Pierre #
Issue Date: Dec-2006
Publisher: Nature Pub. Co.
Series Title: Nature Medicine vol:13 issue:1 pages:35-37
Abstract: Abdominal pain is common in the general population and, in patients with irritable bowel syndrome, is attributed to visceral hypersensitivity. We found that oral administration of specific Lactobacillus strains induced the expression of mu-opioid and cannabinoid receptors in intestinal epithelial cells, and mediated analgesic functions in the gut-similar to the effects of morphine. These results suggest that the microbiology of the intestinal tract influences our visceral perception, and suggest new approaches for the treament of abdominal pain and irritable bowel syndrome.
ISSN: 1078-8956
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Translational Research in GastroIntestinal Disorders
× corresponding author
# (joint) last author

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