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Title: Racial differences in intracellular concentration and transmembrane fluxes of sodium and potassium in erythrocytes of normal male subjects
Authors: M'Buyamba-Kabangu, JR ×
Lijnen, Paul
Groeseneken, D
Staessen, Jan A
Lissens, W
Goossens, Willy
Fagard, Robert
Amery, A #
Issue Date: 1984
Series Title: Journal of hypertension vol:2 issue:6 pages:647-51
Abstract: Erythrocyte concentrations and fluxes of sodium and potassium were investigated in normal black and white male subjects. Erythrocyte sodium concentration was significantly elevated in blacks compared to whites. In single regression analysis erythrocyte sodium concentration was inversely related to the ouabain-sensitive 86Rb-uptake and to the frusemide-sensitive sodium efflux. After adjusting for race, only the relationship between the erythrocyte sodium concentration and the Na+, K+-ATpase pump activity persisted. The sodium-lithium countertransport system was also depressed in the black subjects. No significant difference was observed in erythrocyte potassium concentration between blacks and white. It is probable that, in blacks the decreased active influx of potassium through the sodium-potassium pump was to some extent counter balanced by a reduced efflux of this cationic mediated by the depressed cotransport system. There was no difference in cationic concentrations and fluxes of sodium and potassium between blacks bearing and not bearing haemoglobin S.
ISSN: 0263-6352
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Hypertension and Cardiovascular Epidemiology
Laboratory of Clinical Bacteriology and Mycology
× corresponding author
# (joint) last author

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