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Title: Idebenone treatment in Friedreich's ataxia: neurological, cardiac, and biochemical monitoring
Authors: Buyse, Gunnar ×
Mertens, Luc
Di Salvo, G
Matthijs, I
Weidemann, F
Eyskens, Benedicte
Goossens, Willy
Goemans, Nathalie
Sutherland, G
Van Hove, J L K #
Issue Date: May-2003
Publisher: Advanstar Communications
Series Title: Neurology vol:60 issue:10 pages:1679-81
Abstract: The authors report 1-year prospective data on eight patients with Friedreich ataxia. Idebenone did not halt the progression of ataxia. At the end of therapy, cardiac ultrasound demonstrated significant reduction of cardiac hypertrophy in six of eight patients. Cardiac strain and strain rate imaging showed that the reduction of hypertrophy is preceded by an early and linear improvement in cardiac function. Idebenone reduced erythrocyte protoporphyrin IX levels in five of six patients with elevated baseline levels; however, changes did not consistently relate to cardiac improvement.
ISSN: 0028-3878
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Organ Systems (+)
Section Child - Miscellaneous (-)
Brain & Metabolism Section (-)
Laboratory of Clinical Bacteriology and Mycology
Cardiovascular Developmental Biology
× corresponding author
# (joint) last author

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