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Title: Serological markers for prediction of response to anti-tumor necrosis factor treatment in Crohn's disease
Authors: Esters, Nele ×
Vermeire, Severine
Joossens, Sofie
Noman, M
Louis, E
Belaiche, J
De Vos, M
Van Gossum, Anna
Pescatore, P
Fiasse, R
Pelckmans, P
Reynaert, H
Poulain, D
Bossuyt, Xavier
Rutgeerts, Paul #
Issue Date: Jul-2002
Series Title: American Journal of Gastroenterology vol:97 issue:6 pages:1458-62
Abstract: OBJECTIVES: The use of monoclonal anti-tumor necrosis factor (TNF) antibodies (infliximab, Remicade) is a new therapeutic approach for severe refractory luminal or fistulizing, Crohn's disease (CD). However, up to 30% of patients do not respond to this treatment. So far, no parameters predictive of response to anti-TNF have been identified. Our aim was to determine whether serological markers ASCA (anti-Saccharomyces cerevisiae antibodies) or pANCA (perinuclear antineutrophil cytoplasmic antibodies) could identify Crohn's patients likely to benefit from anti-TNF therapy. METHODS: Serum samples of 279 CD patients were analyzed for ASCA and pANCA before anti-TNF therapy. A blinded physician determined clinical response at week 4 (refractory luminal CD) or week 10 (fistulizing CD) after the first infusion of infliximab (5 mg/kg). RESULTS: Overall, there was no relationship between ASCA or pANCA and response to therapy. However, lower response rates were observed for patients with refractory intestinal disease carrying the pANCA+/ASCA- combination, although this lacked significance (p = 0.067). CONCLUSIONS: In this cohort of infliximab-treated patients, neither ASCA nor pANCA could predict response to treatment. However, the combination pANCA+/ASCA- might warrant further investigation for its value in predicting nonresponse in patients with refractory luminal disease.
URI: 
ISSN: 0002-9270
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Teaching Support Unit, Faculty of Bioscience Engineering
Laboratory of Clinical Bacteriology and Mycology
Translational Research in GastroIntestinal Disorders
Experimental Laboratory Immunology
× corresponding author
# (joint) last author

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