Current Treatment Options in Gastroenterology vol:7 issue:4 pages:265-272
Functional dyspepsia is a heterogeneous disorder where distinct pathophysiological abnormalities are present in subgroups of patients. Accommodation of the proximal stomach to a meal is impaired in up to half of the patients with functional dyspepsia. This is associated with symptoms of early satiety and weight loss. Drug interventions aimed at restoring impaired accommodation are currently being studied.