Title: Fibrinogen and albumin synthesis are regulated at the transcriptional level during the acute phase response
Authors: Moshage, H J ×
Kleter, B E
van Pelt, Jos
Roelofs, H M
Kleuskens, J A
Yap, Sing Hiem #
Issue Date: Nov-1988
Publisher: Elsevier/North Holland
Series Title: Biochimica et Biophysica Acta vol:950 issue:3 pages:450-4
Abstract: During acute inflammation or after administration of monocytic products, an enhanced transcription of the fibrinogen polypeptide genes and a reduced transcription of the albumin gene were observed. The changes in the fibrinogen polypeptide transcriptional rate were found to precede the change in albumin gene transcription. These findings indicate that the altered synthesis of fibrinogen and albumin during inflammation are regulated at the transcriptional level and are most probably mediated by monocytic products (including interleukin-1).
ISSN: 0006-3002
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Hepatology
× corresponding author
# (joint) last author

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