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Title: Long-term outcome in tertiary care functional dyspepsia patients
Authors: Kindt, Sébastien
Mispelon, Leen
Caenepeel, Philip
Arts, Joris
Janssens, Jozef
Tack, Jan #
Issue Date: Apr-2005
Publisher: W b saunders co
Host Document: Gastroenterology vol:128 issue:4 pages:A460-A460
Conference: Digestive Disease Week location:Chicago date:14-19 May 2005
Abstract: Background: A number of studies have reported on the evolution over time of dyspeptic symptoms in the general population (Talley 1992, Lindell 1995, Agreus 1995), but very little is known about the longer-term outcome in patients with functional dyspepsia (FD). FD is a heterogeneous disorder, with different pathophysiological mechanisms underlying the symptom pattern. The aim of this study was to prospectively evaluate the evolution of symptoms in FD patients, seen at a tertiary care center, and to identify factors that influence outcome. Methods: Using telephone interviews and mailed questionnaires, we prospectively followed up FD patients, who underwent a complete pathophysiological investigation. Patients were contacted twice over the last 4 years and were asked to indicate whether their symptoms had worsened, stayed the same, improved or disappeared. Symptom outcome was correlated to demographics, symptom pattern, Helicobacter Pylori status, gastric emptying rate, gastric sensitivity and gastric accommodation at presentation using chi-square and Student t-tests. Results: A response was obtained in 197 of … contacted patients (…%). After a mean follow-up of 265 months, only 2% of patients reported disappearance of symptoms and 20% reported improvement. After a mean follow-up of 635 months, disappearance of symptoms was reported by 22%, improvement by 44%, no change by 29% and worsening by 5%. Younger age at presentation (351 vs. 421, p<0.005), less weight loss (41 vs. 71 kg, p<0.05) and less delayed gastric emptying (t1/2 875 vs. 10720 min, p<0.05) were significant predictors of symptom disappearance at 5 years follow-up. Patients with worsening at late follow-up were less likely to report acute onset (20% vs. 47%). Sex, gastric sensitivity, HP status and gastric accommodation were no predictors of long-term outcome. Conclusion: Although 2-years outcome is poor, the majority of tertiary care FD patients reports improvement or disappearance of symptoms after 5-years follow-up. Younger age, normal gastric emptying rate and limited weight loss at presentation are predictors of long-term favourable outcome.
URI: 
ISSN: 0016-5085
Publication status: published
KU Leuven publication type: IMa
Appears in Collections:Translational Research in GastroIntestinal Disorders
# (joint) last author

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