Title: Further insights into peroxisomal lipid breakdown via alpha- and beta-oxidation
Authors: Van Veldhoven, Paul P ×
Casteels, Minne
Mannaerts, Guy
Baes, Myriam #
Issue Date: May-2001
Publisher: Portland press
Series Title: Biochemical society transactions vol:29 pages:292-298
Abstract: Mammalian peroxisomes degrade fatty carboxylates via two pathways, beta -oxidation and, as shown more recently, alpha -oxidation. The latter process consists of an activation step. followed by a hydroxylation at position 2 and cleavage of the hydroxyacyl-CoA, generating formyl-CoA (precursor of formate/CO2) and, in case of phytanic acid as substrate, pristanal (precursor of pristanic acid). The stereochemistry of the overall pathway, cofactor requirements and substrate specificity of the hydroxylase and the cleavage enzyme, which is homologous with bacterial oxalyl-CoA decarboxylases, will be discussed. With regard to beta -oxidation, peroxisomes contain different acyl-CoA oxidases, multifunctional proteins and thiolases, Based on substrate spectra and stereospecificities of these enzymes, a model was proposed whereby straight chain and branched compounds are degraded by separate pathways. The biochemical findings in mice lacking the D-specific multifunctional protein, however, do not fully support this model. These animals, together with the Pex5(-) mice, might be useful to pinpoint the pathological factors contributing to the brain abnormalities in Zellweger patients. Apparently, the deficit in docosahexaenoic acid, presumably formed via peroxisomal beta -oxidation, is not the major cause.
ISSN: 0300-5127
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Pharmacology Section (-)
Cell Metabolism
Department of Pharmaceutical & Pharmacological Sciences - miscellaneous
Laboratory of Lipid Biochemistry and Protein Interactions
× corresponding author
# (joint) last author

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