Title: Loss of the PlagL2 transcription factor affects lacteal uptake of chylomicrons
Authors: Van Dyck, Frederik ×
Braem, Caroline V
Chen, Zhao
Declercq, Jeroen
Deckers, Rob
Kim, Byeong-Moo
Ito, Susumu
Wu, Michele K
Cohen, David E
Dewerchin, Mieke
Derua, Rita
Waelkens, Etienne
Fiette, Laurence
Roebroek, Anton
Schuit, Frans
Van de Ven, Willem
Shivdasani, Ramesh A #
Issue Date: Nov-2007
Publisher: Cell Press
Series Title: Cell Metabolism vol:6 issue:5 pages:406-413
Abstract: Enterocytes assemble dietary lipids into chylomicron particles that are taken up by intestinal lacteal vessels and peripheral tissues. Although chylomicrons are known to assemble in part within membrane secretory pathways, the modifications required for efficient vascular uptake are unknown. Here we report that the transcription factor pleomorphic adenoma gene-like 2 (PlagL2) is essential for this aspect of dietary lipid metabolism. PlagL2(-/-) mice die from postnatal wasting owing to failure of fat absorption. Lipids modified in the absence of PlagL2 exit from enterocytes but fail to enter interstitial lacteal vessels. Dysregulation of enterocyte genes closely linked to intracellular membrane transport identified candidate regulators of critical steps in chylomicron assembly. PlagL2 thus regulates important aspects of dietary lipid absorption, and the PlagL2(-/-) animal model has implications for the amelioration of obesity and the metabolic syndrome.
ISSN: 1550-4131
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Biochemistry Section (Medicine) (-)
Interdepartemental Stem Cell Institute (-)
Molecular Genetics Section (-)
Molecular and Vascular Biology
Department of Human Genetics - miscellaneous
Gene Expression Unit
Laboratory of Protein Phosphorylation and Proteomics
Laboratory of Phosphoproteomics (-)
Laboratory for Biochemical Neuroendocrinology
Laboratory of Angiogenesis and Vascular Metabolism (Vesalius Research Center) (+)
× corresponding author
# (joint) last author

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