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Title: Rapidly induced, T-cell independent xenoantibody production is mediated by marginal zone B cells and requires help from NK cells
Authors: Li, Shengqiao *
Yan, Yehong *
Lin, Yuan
Bullens, Dominique
Rutgeerts, Omer
Goebels, Jozef
Segers, Constant
Boon, Louis
Kasran, Ahmad
De Vos, Rita
Dewolf-Peeters, Christiane
Waer, Mark ×
Billiau, An #
Issue Date: Dec-2007
Publisher: Amer soc hematology
Series Title: Blood vol:110 issue:12 pages:3926-3935
Abstract: Xenoantibody production directed at a wide variety of T lymphocyte-dependent and T lymphocyte-independent xenoantigens remains the major immunologic obstacle for successful xenotransplantation. The B lymphocyte subpopulations and their helper factors, involved in T-cellindependent xenoantibody production are only partially understood, and their identi-ication will contribute to the clinical applicability of xenotransplantation. Here we show, using models involving T-cell-deficient athymic recipient mice, that rapidly induced, T-cell-independent xenoantibody production is mediated by marginal zone B lymphocytes and requires help from natural killer (NK) cells. This collaboration neither required NK-cell-mediated IFN-gamma production, nor NK-cell-mediated cytolytic killing of xenogeneic target cells. The T-cell-independent IgM xenoantibody response could be partially suppressed by CD40L blockade.
ISSN: 0006-4971
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Pediatric Immunology
Laboratory of Clinical Immunology
Laboratory of Experimental Transplantation
Translational Cell & Tissue Research
Laboratory of Nephrology
* (joint) first author
× corresponding author
# (joint) last author

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