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Title: Glycogen synthase kinase-3 and the Alzheimer-like state of microtubule-associated protein tau
Authors: Mandelkow, E M
Drewes, G
Biernat, J
Gustke, N
Van Lint, Johan
Vandenheede, Jackie
Mandelkow, E # ×
Issue Date: 23-Jan-1993
Series Title: FEBS Letters vol:314 issue:3 pages:315-21
Abstract: The Alzheimer-like state of tau protein includes phosphorylation by a proline-directed Ser/Thr kinase present in normal or pathological human brain. Extending earlier results on MAP kinase, we show here that the proline-directed kinase, GSK3, can induce an Alzheimer-like immune response involving several distinct and phosphorylatable epitopes at Ser-Pro motifs, as well as a gel mobility shift, similar to MAP kinase. Both kinases behave like microtubule-associated proteins in that they co-purify through cycles of assembly and disassembly, and both kinases are directly associated with paired helical filaments.
URI: 
ISSN: 0014-5793
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Biochemistry Section (Medicine) (-)
Laboratory of Protein Phosphorylation and Proteomics
× corresponding author
# (joint) last author

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