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Title: The management of skin reactions in cancer patients receiving epidermal growth factor receptor targeted therapies
Authors: Segaert, Siegfried ×
Tabernero, Josep
Chosidow, Olivier
Dirschka, Thomas
Elsner, Joern
Mancini, Luca
Maughan, Tim
Morere, Jean-Fran Ois
Santoro, Armando
Sobrero, Alberto
Van Cutsem, Eric
Layton, Alison #
Issue Date: Jul-2005
Publisher: Wiley-Blackwell
Series Title: Journal der Deutschen Dermatologischen Gesellschaft vol:3 issue:8 pages:599-606
Abstract: The use of epidermal growth factor receptor (EGFR) inhibitors for the treatment of solid tumours is increasing. However, the tolerability profile for EGFR-inhibitors, such as the monoclonal antibody cetuximab and the tyrosine kinase inhibitor erlotinib, is characterised by a unique group of skin reactions dominated by an acneiform eruption, xerosis, eczema and changes in the hair and nails. The possibility that this skin toxicity correlates with anti-tumour activity offers the potential to titrate dosing on a case-by-case basis. These skin effects may constitute a significant obstacle to treatment compliance. Accordingly, there is a need for consistent, multi-disciplinary management strategies that will allow patients to receive the recommended dosages of such targeted therapies. The eruption responds well to some acne therapies and xerosis can be controlled by standard emollients. Here we present an overview of the treatment options for skin reactions that are available today, and evaluate some of the ways in which the treatment of such EGFR-inhibitor-related skin reactions may be improved in the future. Evidence-based studies are needed to determine the best way to manage these effects.
URI: 
ISSN: 1610-0379
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Dermatology
Translational Research in GastroIntestinal Disorders
Laboratory of Dermatoimmunology (+)
Clinical Digestive Oncology (+)
× corresponding author
# (joint) last author

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