Title: Oligodeoxynucleotides containing 2'-deoxy-1-methyladenosine and Dimroth rearrangement
Authors: Timofeev, Edward N
Mikhailov, Sergey N ×
Zuev, Andrei N
Efimtseva, Ekaterina V
Somers, Robert L
Herdewijn, Piet
Lemaître, Marc M #
Issue Date: 2007
Publisher: Verlag Helvetica Chimica Acta
Series Title: Helvetica Chimica Acta vol:90 pages:928-937
Abstract: 2’-Deoxy-1-methyladenosine was incorporated into synthetic oligonucleotides by phosphoramidite chemistry. Chloroacetyl protecting group and controlled anhydrous deprotection conditions were used to avoid Dimroth rearrangement. Hybridization studies of intramolecular duplexes showed that introduction of a modified residue into the loop region of the oligonucleotide hairpin increases the melting temperature. It was shown that modified oligonucleotides may be easily transformed into oligonucleotides containing 2’-deoxy-N6-methyladenosine.
ISSN: 0018-019X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
× corresponding author
# (joint) last author

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