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Title: Synthesis of 3'-O-phosphonomethyl nucleosides with an adenine
Authors: Viña, Dolores
Wu, Tongfei
Renders, Marleen
Laflamme, Geneviève
Herdewijn, Piet # ×
Issue Date: 2007
Publisher: Pergamon Press
Series Title: Tetrahedron vol:63 pages:2634-2646
Abstract: A synthetic scheme has been developed for the synthesis of 2'-deoxythreose phosphonate nucleosides from b-hydroxy- gbutyrolactone and of 2'-azido erythrose phosphonate nucleosides from dihydroxydihydrofuran-1-one. In addition several alpha-L-arabinofuranose phosphonate nucleosides were synthesized starting from protected alpha-D-galactofuranose. Unfortunately, none of the synthesized compounds show activity in an HIV-1 assay. One of these compounds, a locked phosphonate nucleoside, was evaluated (as diphosphate) for its potential to be incorporated into DNA using HIV-1 reverse transcriptase.
ISSN: 0040-4020
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
× corresponding author
# (joint) last author

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