Title: Enzymatically catalyzed DNA synthesis using L-Asp-dGMP, L-Asp-dCMP, and L-Asp-dTMP
Authors: Terrazas, Montserrat ×
Marlière, Philippe
Herdewijn, Piet #
Issue Date: 2008
Publisher: Verlag Helvetica Chimica Acta
Series Title: Chemistry & Biodiversity vol:5 issue:1 pages:31-39
Abstract: The replacement of the pyrophosphate moiety of deoxynucleoside triphosphates by L-aspartic acid allows incorporation of natural deoxynucleosides into DNA using HIV reverse transcriptase (RT) as enzyme, while retaining the canonical base-pair selectivity. N-Methylation of the L-aspartic acid leaving group results in a reduced fidelity of incorporation.
ISSN: 1612-1872
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
× corresponding author
# (joint) last author

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