Title: Inhibition of HIV-1-induced cytopathogenicity, syncytium formation, and virus-cell binding by naphthalene-disulfonic acids through interaction with the viral envelope gp120 glycoprotein
Authors: Baba, M ×
Schols, Dominique
Mohan, P
De Clercq, Erik
Shigeta, S #
Issue Date: 1993
Publisher: Blackwell science ltd
Series Title: Antiviral chemistry & chemotherapy vol:4 issue:4 pages:229-234
Abstract: Bis-naphthalenedisulphonic acid derivatives with a biphenyl spacer, 4,4'-[4,4'-biphenyldiylbis(sulphonyl-amino)]bis(5-hydroxy-2,7-naphthalenedisulphonic acid) and 3,3'-[4,4'-biphenyldiylbis(sulphonyl-amino)]bis(1,5-naphthalenedisulphonic acid), have previously been reported as potent and selective inhibitors of human immunodeficiency virus type 1 (HIV-1) replication in cell culture. These compounds have also proved inhibitory to syncytium formation in cocultures of MOLT-4 cells with HIV-1-infected HUT-78 cells. They also inhibit the binding of HIV-1 virions to MT-4 cells as determined by a flow cytometric (FACS) method. Further studies on their mechanism of action by the FACS have revealed that the compounds inhibit the binding of anti-gp120 monoclonal antibody to the viral envelope glycoprotein gp120. Binding of OKT4A/Leu3a monoclonal antibody to the cellular CD4 receptor is not affected by the compounds. These results suggest that the anti-HIV-1 activity of the naphthalenedisulphonic acid derivatives can be attributed to inhibition of the gp120-CD4 interaction through binding of the compounds to the viral gp120 antigen.
ISSN: 0956-3202
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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