Title: Vitamin D-3 and the immune system: maintaining the balance in health and disease
Authors: Baeke, Femke
van Etten, Evelyne
Overbergh, Lutgart
Mathieu, Chantal # ×
Issue Date: Jun-2007
Publisher: CABI Pub. on behalf of the Nutrition Society
Series Title: Nutrition Research Reviews vol:20 issue:1 pages:106-118
Abstract: 1,25-Dihydroxyvitamin D-3 (1,25(OH)(2)D-3), the active form of vitamin D-3, is a central player in Ca and bone metabolism. More recently, important immunomodulatory effects have been attributed to this hormone. By binding to its receptor, the vitamin D receptor, 1,25(OH)(2)D-3 regulates the expression of various genes and consequently affects the behaviour of different cell types within the immune system. 1,25(OH)(2)D-3 can potently inhibit pathogenic T cells and gives rise to elevated numbers of regulatory T cells via the induction of tolerogenic dendritic cells. These immunomodulatory activities of 1,25(OH)(2)D-3 have also been proven useful in vivo: administration of 1,25(OH)(2)D-3 in several animal models can prevent or cure different autoimmune diseases and graft rejection. To overcome the dose-limiting side effects of 1,25(OH)(2)D-3 on Ca and bone, less calcaemic structural analogues (alone or in combination with synergistically acting drugs or bone-resorption inhibitors) have been successfully used in animal models. Furthermore, as 1,25(OH)(2)D-3 also contributes to host defence against infectious agents by the induction of antimicrobial responses, this molecule might provide a new strategy to deal with drug-resistant infections. According to the pleiotropic effects of 1,25(OH)(2)D-3 in the immune system, increasing epidemiological data underline the importance of adequate vitamin D intakes in reducing the risk of several autoimmune diseases and infections such as tuberculosis.
ISSN: 0954-4224
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Clinical and Experimental Endocrinology
× corresponding author
# (joint) last author

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