Title: Chronic verrucous varicella tester virus skin lesions: clinical, histological, molecular and therapeutic aspects
Authors: Nikkels, AF ×
Snoeck, Robert
Rentier, B
Pierard, GE #
Issue Date: Sep-1999
Publisher: Blackwell science ltd
Series Title: Clinical and experimental dermatology vol:24 issue:5 pages:346-353
Abstract: The outbreak of HIV infection introduced a new phenomenon in varicella tester virus (VZV) pathology namely the long-standing wart-like skin lesions that are frequently associated with resistance to thymidine kinase (TK)-dependent antiviral agents. This paper reviews the clinical, histological, and molecular aspects and the therapeutic management of these verrucous lesions. The majority of lesions are characterized by chronically evolving, unique or multiple wart-like cutaneous lesions. The main histopathological features include hyperkeratosis, verruciform acanthosis and VZV-induced cytopathic changes with scant or absent cytolysis of infected keratinocytes. The mechanism that establishes the chronic nature of the lesions appears to be associated with a particular pattern of VZV gene expression exhibiting reduced or nondetectable gE and gB synthesis. Drug resistance to TK-dependent antiviral agents is a result of nonfunctional or deficient viral TK. This necessitates alternative therapeutic management using antiviral agents that target the viral DNA polymerase.
ISSN: 0307-6938
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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