Title: In vitro evaluation and biodistribution of a 99mTc-labeled anti-VEGF peptide targeting neuropilin-1
Authors: Perret, Gérard Y ×
Starzec, Anna
Hauet, Nathalie
Vergote, Jackie
Le Pecheur, Marie
Vassy, Roger
Léger, Gérard
Verbeke, Kristin
Bormans, Guy
Nicolas, Patrick
Verbruggen, Alfons
Moretti, Jean-Luc #
Issue Date: Jul-2004
Series Title: Nuclear medicine and biology vol:31 issue:5 pages:575-81
Abstract: Neuropilins (NRP) are receptors of angiogenic vascular endothelial growth factor (VEGF). Their overexpression was correlated with tumor angiogenesis and growth suggesting that their specific targeting could provide a new marker of tumor progression. Here, we observed in vitro that new (99m)Tc-labeled derivative of anti-VEGF heptapeptide, ATWLPPR, binds to NRP1 but not to NRP2. Our radiotracer is stable up to 24 h in human serum and in cysteine challenge. But, its too low affinity and too fast extraction indicate further improvement to give a successful imaging of tumor in vivo.
ISSN: 0969-8051
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Radiopharmaceutical Research
Translational Research in GastroIntestinal Disorders
× corresponding author
# (joint) last author

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