Title: Guiding periodontal pocket recolonization: a proof of concept
Authors: Teughels, Wim ×
Newman, M. G
Coucke, W
Haffajee, A. D
Van Der Mei, H. C
Haake, S. Kinder
Schepers, Evert
Cassiman, Jean-Jacques
Van Eldere, Johan
van Steenberghe, Daniel
Quirynen, Marc #
Issue Date: Nov-2007
Publisher: Int amer assoc dental researchi a d r/a a d r
Series Title: Journal of Dental Research vol:86 issue:11 pages:1078-1082
Abstract: The complexity of the periodontal microbiota resembles that of the gastro-intestinal tract, where infectious diseases are treatable via probiotics. In the oro-pharyngeal region, probiotic or replacement therapies have shown some benefit in the prevention of dental caries, otitis media, and pharyngitis, but their effectiveness in the treatment of periodontitis is unknown. Therefore, this study addressed the hypothesis that the application of selected beneficial bacteria, as an adjunct to scaling and root planing, would inhibit the periodontopathogen recolonization of periodontal pockets. Analysis of the data showed, in a beagle dog model, that when beneficial bacteria were applied in periodontal pockets adjunctively after root planing, subgingival recolonization of periodontopathogens was delayed and reduced, as was the degree of inflammation, at a clinically significant level. The study confirmed the hypothesis and provides a proof of concept for a guided pocket recolonization (GPR) approach in the treatment of periodontitis.
ISSN: 0022-0345
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Prosthetics
Department of Human Genetics - miscellaneous
Laboratory for Experimental and Clinical Microbiology (-)
Laboratory of Clinical Bacteriology and Mycology
Forensic Biomedical Sciences
× corresponding author
# (joint) last author

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