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Title: Cell-based models to study hepatic drug metabolism and enzyme induction in humans
Authors: Vermeir, Marc ×
Annaert, Pieter
Mamidi, Rao N V S
Roymans, Dirk
Meuldermans, Willem
Mannens, Geert #
Issue Date: Jun-2005
Publisher: Informa Healthcare
Series Title: Expert Opinion on Drug Metabolism & Toxicology vol:1 issue:1 pages:75-90
Abstract: Cell-based in vitro models are invaluable tools in elucidating the pharmacokinetic profile of a drug candidate during its drug discovery and development process. As biotransformation is one of the key determinants of a drug's disposition in the body, many in vitro models to study drug metabolism have been established, and others are still being developed and validated. This review is aimed at providing the reader with a concise overview of the characteristics and optimal application of established and emerging in vitro cell-based models to study human drug metabolism and induction of drug metabolising enzymes in the liver. The strengths and weaknesses of liver-derived models, such as primary hepatocytes, either freshly isolated or cryopreserved, and from adult or fetal donors, precision-cut liver slices, and cell lines, including immortalised cells, reporter cell lines, hepatocarcinoma-derived cell lines and recombinant cell lines, are discussed. Relevant cell culture configuration aspects as well as other models such as stem cell-derived hepatocyte-like cells and humanised animal models are also reviewed. The status of model development, their acceptance by health authorities and recommendations for the most appropriate use of the models are presented.
URI: 
ISSN: 1742-5255
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Drug Delivery and Disposition
× corresponding author
# (joint) last author

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