Title: Ca2+ permeation of AMPA receptors in cerebellar neurons expressing Glu receptor 2
Authors: Brorson, JR ×
Zhang, ZH
Vandenberghe, Wim #
Issue Date: Nov-1999
Publisher: Soc neuroscience
Series Title: Journal of Neuroscience vol:19 issue:21 pages:9149-9159
Abstract: AMPA receptors in cultured cerebellar neurons were characterized by whole-cell electrophysiological studies and single cell PCR-based quantitation of subunit mRNA expression. Purkinje neurons consistently expressed high levels of Glu receptor 2 (GluR2) mRNA and AMPA receptors with low but nonzero Ca2+ permeability. Other cerebellar neurons expressed AMPA receptors with a wide range of Ca2+ permeability and of fractional GluR2. These properties correlated on a cell-by-cell basis. Their relationship was well fit by a model that assumed stochastic assembly of subunits and GluR2 dominance in controlling divalent cation permeation, suggesting that AMPA receptor properties in individual neurons may be determined primarily by relative levels of subunit transcription. A fraction of receptors, lacking GluR2, can contribute a highly Ca2+-permeable component to AMPA receptor responses, even in cells expressing GluR2.
ISSN: 0270-6474
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Research Group Experimental Neurology
Laboratory for Parkinson Research
× corresponding author
# (joint) last author

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