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Title: Molecular strategies to inhibit the replication of RNA viruses
Authors: Leyssen, Pieter
De Clercq, Erik
Neyts, Johan # ×
Issue Date: Apr-2008
Publisher: Elsevier/North-Holland
Series Title: Antiviral Research vol:78 issue:1 pages:9-25
Abstract: There are virtually no antiviral drugs available for the treatment of infections with RNA viruses. This is particularly worrisome since most of the
highly pathogenic and emerging viruses are, and will likely continue to be, RNA viruses. These viruses can cause acute, severe illness, including
severe respiratory disease, hemorrhagic fever and encephalitis, with a high case fatality rate. It is important to have potent and safe drugs at hand
that can be used for the treatment or prophylaxis of such infections. Drugs approved for the treatment of RNA virus infections (other than HIV) are
the influenza M2 channel inhibitors, amantadine and rimantadine; the influenza neuraminidase inhibitors, oseltamivir and zanamivir, and ribavirin
for the treatment of infections with respiratory syncytial virus and hepatitis C virus. The molecular mechanism(s) by which ribavirin inhibits viral
replication, such as depletion of intracellular GTP pools and induction of error catastrophe, may not readily allow the design of analogues that are
more potent/selective than the parent drug. Highly pathogenic RNA viruses belong to a variety of virus families, each having a particular replication
strategy, thus offering a wealth of potential targets to selectively inhibit viral replication. We here provide a non-exhaustive review of potential
experimental strategies, using small molecules, to inhibit the replication of several RNA viruses. Other approaches, such as the use of interferon
or other host-response modifiers, immune serum or neutralizing antibodies, are not addressed in this review.
ISSN: 0166-3542
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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