Title: Pleiotropic effects of Drosophila neuralized on complex behaviors and brain structure
Authors: Rollmann, Stephanie A ×
Zwarts, Liesbeth
Edwards, Alexis C
Yamamoto, Akihiko
Callaerts, Patrick
Norga, Koenraad
Mackay, Trudy F. C
Anholt, Robert R. H #
Issue Date: Jul-2008
Publisher: Genetics Society of America
Series Title: Genetics vol:179 issue:3 pages:1327-1336
Abstract: Understanding how genotypic variation influences variation in brain structures and behavioral phenotypes represents a central challenge in behavioral genetics. In Drosophila melanogaster, the neuralized (neur) gene plays a key role in development of the nervous system. Different P-element insertional mutations of neur allow the development of viable and fertile adults with profoundly altered behavioral phenotypes that depend on the exact location of the inserted P element. The neur mutants exhibit reduced responsiveness to noxious olfactory and mechanosensory stimulation and increased aggression when limited food is presented after it period of food deprivation. These behavioral phenotypes are correlated with distinct structural changes in integrative centers in the brain, the mushroom bodies, and the ellipsoid body of the central complex. Transcriptional profiling of neur mutants revealed considerable overlap among ensembles of coregulated genes in the different mutants, but also distinct allele-specific differences. The diverse phenotypic effects arising from nearby P-element insertions in neur provide it new appreciation of, the concept of allelic effects on phenotype, in which the wild type and null mutant are at the extreme ends of a continuum of pleiotropic allelic effects.
ISSN: 0016-6731
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Pediatric Hematology & Oncology Section (-)
Laboratory of Behavioral and Developmental Genetics
Associated Laboratories - miscellaneous (-)
Department of Human Genetics - miscellaneous
× corresponding author
# (joint) last author

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