Title: Synthesis and antiviral activity of imidazo[1,2-a]pyridines
Authors: Lhassani, M ×
Chavignon, O
Chezal, JM
Teulade, JC
Chapat, JP
Snoeck, Robert
Andrei, Graciela
Balzarini, Jan
De Clercq, Erik
Gueiffier, A #
Issue Date: Mar-1999
Publisher: Editions scientifiques medicales elsevier
Series Title: European journal of medicinal chemistry vol:34 issue:3 pages:271-274
Abstract: Imidazo[1,2-a]pyridines bearing a 3-(dithiolan-, dioxolan- or oxathiolan-2-yl) substituent were synthesized from the corresponding aldehydes. The dithiolanyl derivative 6a proved active against cytomegalovirus at an inhibitory concentration (IC50) of 16 mu M, while the oxathiolanyl compound 6c inhibited respiratory syncytial virus (IC50: 58 mu M) The thioacetal 7 was active against cytomegalovirus at an IC50 of 3.1 mu M. None of the compounds had anti-HIV activity and were not inhibitory against other RNA and DNA viruses evaluated. Compounds 6a,c and 7 had in vitro selectivity indexes (ratio cytostatic concentration/antivirally active concentration) ranging between 8 and 10. (C) Elsevier, Paris.
ISSN: 0223-5234
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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