European journal of medicinal chemistry vol:34 issue:3 pages:271-274
Imidazo[1,2-a]pyridines bearing a 3-(dithiolan-, dioxolan- or oxathiolan-2-yl) substituent were synthesized from the corresponding aldehydes. The dithiolanyl derivative 6a proved active against cytomegalovirus at an inhibitory concentration (IC50) of 16 mu M, while the oxathiolanyl compound 6c inhibited respiratory syncytial virus (IC50: 58 mu M) The thioacetal 7 was active against cytomegalovirus at an IC50 of 3.1 mu M. None of the compounds had anti-HIV activity and were not inhibitory against other RNA and DNA viruses evaluated. Compounds 6a,c and 7 had in vitro selectivity indexes (ratio cytostatic concentration/antivirally active concentration) ranging between 8 and 10. (C) Elsevier, Paris.