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Title: Facile preparation of 9h-pyrimido[4,5-b][1,4]diazepine derivatives from 4,5-diaminopyrimidines and ethyl pyruvate
Authors: Melguizo, M ×
Sanchez, A
Nogueras, M
Low, Jn
Howie, Ra
Andrei, Graciela
De Clercq, Erik #
Issue Date: Nov-1994
Publisher: Pergamon-elsevier science ltd
Series Title: Tetrahedron vol:50 issue:47 pages:13511-13522
Abstract: A facile novel procedure to obtain (+/-)-6,8,-diethoxycarbonyl-6-methyl-9-H-pyrimidol[4,5-6] [1,4]diazepines from 4,5-diaminopyrimidines and ethyl pyruvate is described. The structure of pyrimidol[4,5-b] [1,4]diazepine derivatives for the products of this reaction was confirmed by single crystal X-ray diffraction analysis. The procedure proved to be of wide scope with reference to the substituent of the starting pyrimidines. The results of the biological test as anticancer and antiviral agents performed with several of the newly synthesized compounds are presented.
URI: 
ISSN: 0040-4020
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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