Title: Alkyne-azide click chemistry mediated carbanucleosides synthesis
Authors: Broggi, Julie ×
Joubert, Nicolas
Aucagne, Vincent
Berteina-Raboin, Sabine
Diez-Gonzalez, S
Nolan, Steve
Topalis, Dimitrios
Deville-Bonne, Dominique
Balzarini, Jan
Neyts, Johan
Andrei, Graciela
Snoeck, Robert
Agrofoglio, Luigi A #
Issue Date: 2007
Publisher: Marcel Dekker
Series Title: Nucleosides, Nucleotides & Nucleic Acids vol:26 issue:10-12 pages:1391-1394
Conference: XVII International Round Table on Nucleosides, Nucleotides and Nucleic Acids location:Bern, Switzerland date:3-7 September 2006
Abstract: Hitherto unknown 1,4-disubstituted-[1,2,3]-triazolo-4',4'-dihydroxymethyl-3'-deoxy carbanucleosides were synthesized based on a "click approach." Various alkynes were introduced on a key azido intermediate by the "click" 1,3-dipolar Huisgen cycloaddition. Their antiviral activities and cellular toxicities were evaluated on vaccinia virus. None of the synthesized compounds exhibited a significant antiviral activity.
ISSN: 1525-7770
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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