6th International Conference on Head and Neck Cancer, Date: 2004/08/07 - 2004/08/11, Location: Washinton DC, USA
Proceedings of the 6th International Conference on Head and Neck Cancer – American Head and Neck Society
Author:
Keywords:
prognosis, neoplasm, salivary gland, index, validation
Abstract:
We previously performed a Cox proportional hazards regression analysis and constructed a prognostic model, based on a “source population” of 151 parotid carcinoma patients from the Netherlands Cancer Institute. The resulting information was used to create a prognostic index (Vander Poorten VLM, Balm AJM, Hilgers FJM, Tan IB, Loftus-Coll BM, Keus RB, et al. The development of a prognostic score for patients with parotid carcinoma. Cancer 1999;85:2057-67). Table 1 displays PS1, a pre-treatment index, and PS2, incorporating data from the surgical specimen. For one patient, such an index sums the weighted contributions of each important clinical and histological characteristic into one number, corresponding to the outcome, tumor recurrence. In this way for instance, a patient of 74 years old with a 3 cm painful suspect nodule in the left parotid gland, without sings of facial nerve weakness, skin invasion or palpable neck nodes, can be told before treatment to have a 59% chance of being tumor free 5 years following standard treatment, if the lesion proves to be malignant.