Title: Chromosome 10q harbors a susceptibility locus for bipolar disorder in Ashkenazi Jewish families
Authors: Venken, T ×
Alaerts, M
Souery, D
Goossens, D
Sluijs, S
Navon, R
Van Broeckhoven, C
Mendlewicz, J
Del-Favero, J
Claes, Stephan #
Issue Date: Apr-2008
Publisher: Stockton Press
Series Title: Molecular Psychiatry vol:13 issue:4 pages:442-450
Abstract: We report the results of a 10 cM density genome-wide scan and further fine mapping of three chromosomal candidate regions in 10 Belgian multigenerational families with bipolar (BP) disorder. This two-stage approach revealed significant evidence for linkage on chromosome 10q21.3-10q22.3, showing a maximum multipoint parametric heterogeneity logarithm of odds (HLOD) score of 3.28 and a nonparametric linkage (NPL) score of 4.00. Most of the chromosome 10q evidence was derived from a single, large Ashkenazi Jewish pedigree. Haplotype analysis in this pedigree shows that the patients share a 14-marker haplotype, defining a chromosomal candidate region of 19.2 cM. This region was reported previously as a candidate region for BP disorder in several independent linkage analysis studies and in one large meta-analysis. It was also implicated in a linkage study on schizophrenia (SZ) in Ashkenazi Jewish families. Additionally, we found suggestive evidence for linkage on chromosome 19q13.2-13.4 (HLOD 2.01, NPL 1.09) and chromosome 7q21-q22 (HLOD 1.45, NPL 2.28). Together, these observations suggest that a gene located on chromosome 10q21.3-10q22.3 is underlying the susceptibility both for SZ and for BP disorder in at least the Ashkenazi Jewish population.Molecular Psychiatry advance online publication, 19 June 2007; doi:10.1038/
ISSN: 1359-4184
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Research Group Psychiatry
× corresponding author
# (joint) last author

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