The corticotropin-releasing hormone binding protein is associated with major depression in a population from northern Sweden

Claes, Stephan; Villafuerte, S; Forsgren, T; Sluijs, S; Del-Favero, J; Adolfsson, R; Van Broeckhoven, C

doi:10.1016/S0006-3223(03)00425-6

The corticotropin-releasing hormone binding protein is associated with major depression in a population from northern Sweden

Author:

Claes, Stephan

Villafuerte, S ; Forsgren, T ; Sluijs, S ; Del-Favero, J ; Adolfsson, R ; Van Broeckhoven, C

Keywords:

crh binding protein, crh, major depression, hpa axis, pituitary-adrenal axis, high familial risk, haplotype frequencies, affective-disorders, crh test, dsm-iv, childhood, responses, stress, abuse, Science & Technology, Life Sciences & Biomedicine, Neurosciences, Psychiatry, Neurosciences & Neurology, CRH binding protein, CRH, HPA axis, PITUITARY-ADRENAL AXIS, HIGH FAMILIAL RISK, HAPLOTYPE FREQUENCIES, CRH TEST, DSM-IV, RESPONSES, ACCURACY, ANXIETY, STRESS, ABUSE, Aged, Carrier Proteins, Case-Control Studies, Chromatography, High Pressure Liquid, Depressive Disorder, Major, Genotype, Humans, Male, Middle Aged, Mood Disorders, Polymerase Chain Reaction, Polymorphism, Single Nucleotide, Sweden, 06 Biological Sciences, 11 Medical and Health Sciences, 17 Psychology and Cognitive Sciences, 31 Biological sciences, 32 Biomedical and clinical sciences, 52 Psychology

Abstract:

Background: Recent research suggests that central corticotropin releasing hormone hyperdrive is an important neurobiological risk factor for developing major depression. The availability of free corticotropin releasing hormone in the central nervous system is tightly regulated by the expression of corticotropin releasing hormone binding protein. Therefore, the gene encoding for corticotropin releasing hormone binding protein is a functional candidate gene for major depression.