ITEM METADATA RECORD
Title: Novel non-nucleoside human cytomegalovirus inhibitors based upon TSAO nucleoside derivatives: structure-activity relationships
Authors: de Castro, Sonia ×
Andrei, Graciela
Snoeck, Robert
Balzarini, Jan
Camarasa, María-José
Velázquez, Sonsoles #
Issue Date: 2007
Publisher: Marcel Dekker
Series Title: Nucleosides, Nucleotides & Nucleic Acids vol:26 issue:6-7 pages:625-628
Conference: XVII International Round Table on Nucleosides, Nucleotides and Nucleic Acids location:Bern, Switzerland date:3-7 September 2006
Abstract: TSAO derivatives are a unique group of potent and highly specific inhibitors of HIV-1 replication. We have recently reported 4''-ureido TSAO derivatives that are devoid of anti-HIV-1 activity, but inhibit human cytomegalovirus with an activity comparable to that of Ganciclovir. We herein report the synthesis and biological evaluation of novel 4''-ureido TSAO derivatives in order to evaluate the structural features required for anti-HCMV activity. Interestingly, these studies revealed that the compounds may inhibit HCMV at the DNA polymerase step via a non-nucleoside mechanism.
ISSN: 1525-7770
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

Files in This Item:

There are no files associated with this item.

Request a copy

 




All items in Lirias are protected by copyright, with all rights reserved.

© Web of science