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Title: Iron as a potential co-factor in the pathogenesis of Kaposi's sarcoma?
Authors: Simonart, T ×
Noel, J C
Andrei, Graciela
Parent, D
Van Vooren, J P
Hermans, P
Lunardi-Yskandar, Y
Lambert, C
Dieye, T
Farber, C M
Liesnard, C
Snoeck, Robert
Heenen, M
Boelaert, J R #
Issue Date: Dec-1998
Publisher: Wiley-Liss
Series Title: International Journal of Cancer vol:78 issue:6 pages:720-6
Abstract: The role of iron in the pathogenesis of several tumours is being increasingly investigated. In particular, its involvement in the pathogenesis of Kaposi's sarcoma (KS) is suggested by the distribution of the endemic form of KS corresponding to continental rifts and associated iron-oxide-rich volcanic clays. We investigated in vitro to what extent iron supplementation or withdrawal could affect the growth of KS-derived cells, by analysing the effects of adding iron salts (iron chloride and ferric nitrilotriacetate) and/or reducing iron by iron chelators (desferrioxamine) on KS-derived cell cultures. The addition of iron salts strongly stimulated the growth of KS cells, as reflected by increase in thymidine incorporation and cell number. Conversely, desferrioxamine and deferiprone inhibited cell growth. The inhibitory effect of iron chelation was more pronounced on rapidly dividing basic fibroblast-growth-factor-stimulated cells. These results may point to a novel therapeutic approach to KS.
URI: 
ISSN: 0020-7136
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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