Title: Chemical etiology of nucleic acids: aminopropyl nucleic acids (APNAs)
Authors: Zhou, Ding
Froeyen, Mathy
Rozenski, Jef
Van Aerschot, Arthur
Herdewijn, Piet # ×
Issue Date: 2007
Publisher: Wiley-v c h verlag gmbh
Series Title: Chemistry & biodiversity vol:4 issue:4 pages:740-761
Abstract: Aminopropyl nucleic acids (APNAs) are constitutionally simple nucleic acid alternatives with one stereogenic center per nucleotide, and with the potential to hybridize with RNA and to exert catalytic functions. We have developed a protecting group strategy to synthesize APNAs, although in a not very efficient way. Isolation and purification of APNAs proved to be difficult. Their structures might be more suited to function as potential catalytic polymers than as information systems that may evolve into RNA.
ISSN: 1612-1872
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
× corresponding author
# (joint) last author

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