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Title: Fmoc-protected altritol phosphoramidite building blocks and their application in the synthesis of altritol nucleic acids (ANAs)
Authors: Abramov, Mikhail ×
Schepers, Guy
Van Aerschot, Arthur
Herdewijn, Piet #
Issue Date: Mar-2007
Publisher: Wiley-v c h verlag gmbh
Series Title: European journal of organic chemistry issue:9 pages:1446-1456
Abstract: Fmoc-protected altritol nucleoside phosphoramidite building blocks with adenine, guanine, thymine, uracil, cytosine and 5-methylcytosine as bases have been synthesized. These building blocks were used for the synthesis of altritol nucleic acid (ANA) and chimeric ANA-RNA oligonucleotides. Whilst the yields of oligonucleotides were lower than those obtained with 3'-O-benzoyl-protected altritol building blocks, the excellent compatibility with Pac-RNA chemistry for the synthesis of chimeric oligonucleotides makes Fmoc a valuable protecting group for the secondary alcohol functions of the sugar moieties of nucleosides for oligonucleotide synthesis. ((c) Wiley-VCH Verlag GmbH & Co.
ISSN: 1434-193X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry
× corresponding author
# (joint) last author

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