Title: 2 '-O-hydroxyalkoxymethylribonucleosides and their incorporation into oligoribonucleotides
Authors: Mikhailov, Sergey N
Bobkov, Georgii V
Brilliantov, Kyrill V
Rozenski, Jef
Van Aerschot, Arthur
Herdewijn, Piet ×
Fisher, Michael H
Juliano, Rudolph L #
Issue Date: 2007
Publisher: Taylor & francis inc
Series Title: Nucleosides nucleotides & nucleic acids vol:26 issue:10-12 pages:1509-1512
Abstract: A simple and efficient method for the preparation of pyrimidine 2'-O-hydroxyethoxymethylribonucleosides and 2'-O-hydroxypropoxymethylribonucleosides has been developed. These modified nucleosides were incorporated into oligoribonucleotides, which were shown to form stable RNA/RNA duplexes. The effect of 2'-O-modification in the antisense and sense strands of small interference RNA was evaluated in multi-drug resistant NIH 3T3 cells.
ISSN: 1525-7770
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
× corresponding author
# (joint) last author

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