Title: Conformational and chiral selection of oligonucleotides
Authors: Froeyen, Mathy
Morvan, Francois
Vasseur, Jean-Jacques
Nielsen, Peter
Van Aerschot, Arthur
Rosemeyer, Helmut
Herdewijn, Piet # ×
Issue Date: 2007
Publisher: Wiley-v c h verlag gmbh
Series Title: Chemistry & biodiversity vol:4 issue:4 pages:803-817
Abstract: In view of a better understanding of chiral selection of oligonucleotides, we have studied the hybridization of D- and L-CNA (cyclohexane nucleic acids) and D- and t.-DNA, with chiral D-beta-homoDNA and achiral PNA (peptide nucleic acids). PNA hybridizes as well with D-DNA, L-DNA as with D-beta-homo-DNA. The structure of the PNA D-beta-homo-DNA complex is different from the PNA . DNA duplexes. D-CNA prefers D-DNA as hybridization partner, While L-CNA prefers D-beta-homo-DNA as hybridization partner. ne conformation of the enantiomeric oligonucleotides D-CNA and L-CNA in the supramolecular complex with D-DNA and D-beta-homo-DNA, respectively, is different. These data may contribute to the confirmation of a hypothesis of the existence of achiral informative polymers as RNA predecessor, and to the understanding of homochirality of nucleic acids.
ISSN: 1612-1872
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
× corresponding author
# (joint) last author

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