Title: Synthesis and evaluation of hexitol nucleoside congeners as ambiguous nucleosides
Authors: Lambertucci, Catia ×
Schepers, Guy
Cristalli, Gloria
Herdewijn, Piet
Van Aerschot, Arthur #
Issue Date: Mar-2007
Publisher: Pergamon-elsevier science ltd
Series Title: Tetrahedron letters vol:48 issue:12 pages:2143-2145
Abstract: A series of anhydrohexitol nucleoside congeners was synthesized as ambiguous or so-called universal nucleosides and was evaluated for their hybridization potential and discrimination properties. The 1,5-anhydro-2,3-dideoxy-2-(5-nitroindazol-1-yl)-D-arabino-hexitol 4e showed the lower spread in T-m values upon hybridization to the natural bases, with minimal destabilization, and therefore behaved as a true ambiguous nucleoside. (c) 2007 Published by Elsevier Ltd.
ISSN: 0040-4039
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
× corresponding author
# (joint) last author

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