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Title: Non-replication of the brain-derived neurotrophic factor (BDNF) association in bipolar affective disorder: A Belgian patient-control study
Authors: Oswald, P ×
Del-Favero, J
Massat, I
Souery, D
Claes, Stephan
Van Broeckhoven, C
Mendlewicz, J #
Issue Date: Aug-2004
Publisher: Wiley-Liss
Series Title: American Journal of Medical Genetics vol:129B issue:1 pages:34-35
Abstract: This patient-control association study was conducted to investigate a possible association of two single nucleotide polymorphisms (SNPs), g.11757C > G and g.196G > A, in the brain-derived neurotrophic factor (BDNF) with bipolar affective disorder (BPAD). Two hundred seventy-five individuals of Belgian origin (at least two generations of Belgian ancestors) were genotyped (112 BPAD and 163 controls). No significant differences were found in the frequency of genotypes and alleles of g.196G>A (P=0.37 and 0.94, respectively) and g. 11757C > G (P = 0.49 and 0.59, respectively) between controls and BPAD patients. An haplotype analysis revealed no difference between patients and controls (P = 0.44). We failed to replicate previous findings implicating BDNF in the aetiology of BPAD. However, BDNF remains an interesting target for future genetic studies and should be tested in prospective pharmacogenetic therapeutic trials. (C) 2004 Wiley-Liss, Inc.
ISSN: 0148-7299
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Research Group Psychiatry
× corresponding author
# (joint) last author

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