Title: Arsenic trioxide (As2O3) and its role in the treatment of acute promyelocytic leukemia
Authors: Platteau, Elise
Vandenberghe, Peter
Billiet, Johan
Van Hoof, Achiel
Roelandt, Philip
Vandroogenbroeck, Jan
Selleslag, Dominiek # ×
Issue Date: Feb-2006
Series Title: Tijdschrift voor geneeskunde vol:62 issue:3 pages:223-234
Abstract: The importance of arsenic trioxide in the treatment of acute promyelocytic leukemia (APL) is illustrated by the hereby reported clinical case. 20% of the patients relapse after treatment with the standard therapeutic methods, i.e. all-trans retinoic acid (ATRA) and chemotherapy.
Over the last 10 years several studies proved arsenic trioxide to be effective in relapsed acute promyelocytic leukemia, with high complete remission rates. Although the drug is safe in patients who relapsed, severe hepatotoxicity has been observed in some newly diagnosed patients.
The action of mechanism is yet not completely understood, but one assumes that arsenic trioxide induces differentiation and apoptosis in APL cells. Consolidation therapy is needed, as it is after treatment with ATRA; still, the optimal therapy for consolidation remains currently uncertain.
The potentials of arsenic trioxide in the treatment of malignancies other than acute promyelocytic leukemia are under investigation.
ISSN: 0371-683X
Publication status: published
KU Leuven publication type: AT
Appears in Collections:Hepatology
Clinical Genetics Section (-)
Department of Human Genetics - miscellaneous
× corresponding author
# (joint) last author

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