Title: Broncho-alveolar lavage fluid recovery correlates with airway neutrophilia in lung transplant patients
Authors: Vanaudenaerde, Bart ×
Wuyts, Wim
Geudens, Nele
Nawrot, Tim
Vos, Robin
Dupont, Lieven
Van Raemdonck, Dirk
Verleden, Geert #
Issue Date: Mar-2008
Publisher: Bailliè€re Tindall, in association with the British Thoracic Society
Series Title: Respiratory Medicine vol:102 issue:3 pages:339-347
Abstract: Broncho-alveolar lavage (BAL) is important to assess airway inflammation. There is debate about the volume instilled, but the variation of BAL fluid recovery (BFR) has received little attention. We investigated the association between BFR and rejection/infection status after lung transplantation (LTx). We combined clinical findings, FEV(1), transbronchial biopsies and BAL analysis (BFR, interleukin-8 (IL8), cell counts, microbiology) of 115 samples/LTx patients. The patients were divided into 4 groups: stable (subdivided in colonized and non-colonized), acute rejection (AR), Bronchiolitis Obliterans Syndrome (BOS) and infection. BFR was significantly lower in AR, BOS and infection, and correlated with the severity of AR and BOS. A 10ml decrease of BFR was associated with a FEV(1) decrease of 4.4% and a %neutrophils and IL8 increase of 9.6% and 9.7pg/ml, respectively. Colonized stable patients had no significant differences in airway inflammation, FEV(1) and BFR compared to the non-colonized stable patients. We conclude that a low BFR is an indicator of lung rejection or infection. BFR variation is related to airway obstruction and neutrophilic inflammation, which can cause an increased compliance of the airway wall, making it more collapsible. Airway colonization in stable patients had no effect on airway inflammatory parameters, BFR and FEV(1).
ISSN: 0954-6111
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Thoracic Surgery
Occupational, Environmental and Insurance Medicine (-)
× corresponding author
# (joint) last author

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