Title: Morbidity and mortality in compensated cirrhosis type C: a retrospective follow-up study of 384 patients
Authors: Fattovich, G ×
Giustina, G
Degos, F
Tremolada, F
Diodati, G
Almasio, P
Nevens, Frederik
Solinas, A
Mura, D
Brouwer, J T
Thomas, H
Njapoum, C
Casarin, C
Bonetti, P
Fuschi, P
Basho, J
Tocco, A
Bhalla, A
Galassini, R
Noventa, F
Schalm, S W
Realdi, G #
Issue Date: Mar-1997
Series Title: Gastroenterology vol:112 issue:2 pages:463-72
Abstract: BACKGROUND & AIMS: Few data are available concerning the long-term prognosis of chronic liver disease associated with hepatitis C virus infection. This study examined the morbidity and survival of patients with compensated cirrhosis type C. METHODS: A cohort of 384 European cirrhotic patients was enrolled at seven tertiary referral hospitals and followed up for a mean period of 5 years. Inclusion criteria were biopsy-proven cirrhosis, abnormal serum aminotransferase levels, absence of complications of cirrhosis, and exclusion of hepatitis A and B viruses and of metabolic, toxic, or autoimmune liver diseases. RESULTS: Antibodies against hepatitis C virus were positive in 98% of 361 patients tested. The 5-year risk of hepatocellular carcinoma was 7% and that of decompensation was 18%. Death occurred in 51 patients (13%), with 70% dying of liver disease. Survival probability was 91% and 79% at 5 and 10 years, respectively. Two hundred five patients (53%) were treated with interferon alfa. After adjustment for clinical and serological differences at baseline between patients treated or not treated with interferon, the 5-year estimated survival probability was 96% and 95% for treated and untreated patients, respectively. CONCLUSIONS: In this cohort of patients, life expectancy is relatively long, in agreement with the morbidity data showing a slowly progressive disease.
ISSN: 0016-5085
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Hepatology
× corresponding author
# (joint) last author

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