Title: Lack of disease recurrence in diabetic BB/Pfd rats after syngeneic islet transplantation
Authors: Kuttler, B ×
Mathieu, Chantal
Waer, Mark
Hahn, H J
Bouillon, Roger #
Issue Date: Feb-1993
Series Title: Autoimmunity vol:15 issue:2 pages:107-12
Abstract: Restimulation of autoreactivity in two different BB rat sublines of the same origin (Ottawa, Canada) was investigated by syngeneic islet transplantation into diabetic animals. Despite identical methods and conditions recurrence of hyperglycaemia was observed in BB/OK rats (Karlsburg, Germany) but not in BB/Pfd rats (Leuven, Belgium). Pancreatic morphology at the time of transplantation revealed significant differences in islet volume density and the degree of insulitis. Additionally, marked differences in the phenotypical composition of cells infiltrating the islets were observed. A loss of autoimmune memory in BB/Pfd rats is discussed as a probable reason for the lack of disease recurrence in those animals.
ISSN: 0891-6934
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medical Clerkships Centers
Laboratory of Nephrology
Clinical and Experimental Endocrinology
Laboratory of Experimental Transplantation
× corresponding author
# (joint) last author

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