Title: Phase I and pharmacokinetic study of E7070, a chloroindolyl-sulfonamide anticancer agent, administered on a weekly schedule to patients with solid tumors
Authors: Dittrich, C ×
Dumez, Herlinde
Calvert, H
Hanauske, A
Faber, M
Wanders, J
Yule, M
Ravic, M
Fumoleau, P #
Issue Date: Nov-2003
Publisher: Amer assoc cancer research
Series Title: Clinical Cancer Research vol:9 issue:14 pages:5195-5204
Abstract: Purpose: E7070 is a sulfonamide that induces arrest at the G(1)-S boundary with subsequent dose and exposure-dependent apoptosis. The objectives of this study were (a) to determine the maximum-tolerated dose (MTD) and recommended safe dose (RD) of E7070 for additional evaluation, (b) to define the dose limiting toxicity(ies) [DLT(s)], (c) to study the pharmacokinetics of E7070, and (d) to seek preliminary evidence of antitumor activity.
ISSN: 1078-0432
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Experimental Oncology
× corresponding author
# (joint) last author

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