Title: Progressive multifocal leukoencephalopathy after natalizumab therapy for Crohn's disease
Authors: Van Assche, Gert
Van Ranst, Marc
Sciot, Raphael
Dubois, Bénédicte
Vermeire, Severine
Noman, Maja
Verbeeck, Jannick
Geboes, Karel
Robberecht, Wim
Rutgeerts, Paul # ×
Issue Date: 28-Jul-2005
Series Title: The New England Journal of Medicine vol:353 issue:4 pages:362-368
Abstract: The prior diagnosis of fatal astrocytoma in a 60-year-old man with Crohn's disease treated with natalizumab, a monoclonal antibody against alpha4 integrins, was reclassified as JC virus-related progressive multifocal leukoencephalopathy (PML). Analysis of frozen serum samples showed that JC virus DNA had appeared in the serum three months after the initiation of open-label natalizumab monotherapy and two months before the appearance of symptomatic PML. There was staining of the brain lesion for polyomavirus. This case report, along with two others, suggests that anti-alpha4-integrin therapy can result in JC virus-induced PML.
ISSN: 0028-4793
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Translational Research in GastroIntestinal Disorders
Laboratory of Clinical and Epidemiological Virology (Rega Institute)
Translational Cell & Tissue Research
Research Group Experimental Neurology
Laboratory for Neurobiology (Vesalius Research Center)
Laboratory for Neuroimmunology
× corresponding author
# (joint) last author

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