Title: Synthesis of spirocyclic pyridoazepines as analogues of galanthamine by nucleophilic aromatic substitution of 3-substituted 2-chloropyridines
Authors: Vanlaer, Sofle
De Borggraeve, Wim
Compernolle, Frans # ×
Issue Date: Oct-2007
Publisher: Wiley-v c h verlag gmbh
Series Title: European journal of organic chemistry issue:30 pages:4995-4998
Abstract: In this report we describe the synthesis of spirocyclic pyridoazepines starting from easily available precursors. The key step of our synthesis is an intramolecular nucleophilic aromatic substitution of the appropriate 3-substituted 2-chloropyridines. The final compounds, designed as simplified analogues of the alkaloid galanthamine, showed significant acetylcholinesterase inhibition activity.
ISSN: 1434-193X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Design and Synthesis
Chemistry - miscellaneous
× corresponding author
# (joint) last author

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