Title: Stereoselective intramolecular Diels-Alder reactions of 3-alkenyl(oxy)-2(1H)-pyrazinones
Authors: De Borggraeve, Wim
Rombouts, FJR
Verbist, BMP
Van der Eycken, Erik
Hoornaert, Georges # ×
Issue Date: Jan-2002
Publisher: Pergamon-elsevier science ltd
Series Title: Tetrahedron letters vol:43 issue:3 pages:447-449
Abstract: Dichloropyrazinones are reacted with alkenolates or a Grignard reagent in order to tether a dienophilic side-chain at the 3-position. The compounds smoothly undergo intramolecular Diels -Alder reaction forming tricyclic ring systems. The reactions proceed completely stereoselective yielding only endo adducts. In the case of the alkenylpyrazinone, the core skeleton of the breviamides is obtained. (C) 2002 Elsevier Science Ltd. All rights reserved.
ISSN: 0040-4039
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Design and Synthesis
Chemistry - miscellaneous
× corresponding author
# (joint) last author

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