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Title: Identification and expression of the motilin precursor in the guinea pig
Authors: Xu, L ×
Depoortere, Inge
Tang, M
Peeters, TL #
Issue Date: Feb-2001
Publisher: Elsevier science bv
Series Title: FEBS Letters vol:490 issue:1-2 pages:7-10
Abstract: Motilin has never been isolated from rodents, the most frequently used laboratory animals, despite several attempts, We have isolated and sequenced the motilin precursor from duodenal mucosa of guinea pig (GenBank accession number AF323752) and studied its expression in several tissues, The percent homology with human motilin is the lowest yet observed due to several unique substitutions in the C-terminal end, As expected, the precursor was present in the gut mucosa with the exception of the gastric corpus, It was also present in medulla oblongata, nucleus of the solitary tract, hypophysis, spinal cord, hypothalamus, and cerebellum but not in the cerebral cortex, For the first time ne demonstrated motilin expression in the thyroid. (C) 2001 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.
ISSN: 0014-5793
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Translational Research in GastroIntestinal Disorders
× corresponding author
# (joint) last author

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